video is good but audio not sync and strange noise create

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hello
I win 7 rtm
cpu quad q6600
NVIDIA GeForce GTX 260
asus P5B
Audio onboard

when I do connect a divx file in mkv HD video is good but sound strange noises in the background created

I have installed divx 7 etc etc.

ah I forgot

I save my files mkv on a external usb hdd

is possible that there is a slowdown due to the loading and indexing of the files?

I use windows media center and everything is fine.